"A Man can't make a mistake can't make anything"
Showing posts with label mortality. Show all posts
Showing posts with label mortality. Show all posts

Sunday, 22 June 2014

BURN / COMBUSTIO IN CHILDREN



Epidemiology
·       3rd leading cause of accidental death amongst children
·       Mortality – higher for children and the elderly
·       2005: >120,000 children <15 years of age received care in ED for burns / COMBUSTIO
·       Children <5 years old: 65% scald injuries
·       5-20 years old: 27% scald injuries
·       Non-accidental burns: estimated as high as 20% of burn admissions
·       Inhalational injury increases mortality significantly

Pathophysiology:
1.     Local injury: heat denatures and coagulates protein => irreversible tissue destruction
o   Surrounding this => zone of decreased tissue perfusion (salvageable tissue)
o   Young children have thinner skin => deeper burns
o   Increased capillary leak around burn
2.     Systemic response: release of vasoactive mediators from tissue: cytokines, prostaglandins, O2 radicals
o   >15% burn in young children, >20% burn in older children: systemic response to mediators
o   Systemic capillary leak lasts 18-24 hours => burn shock/SIRS
o   Immunosppuression
o   Local destruction of RBC’s
o   Myocardial depression
o   Hypermetabolic response: catecholamine release, glucagon, cortisol elevation
3.     Advocacy: with140-150 degree water (normal for home water heater): 3rd degree burn in approximately 2 seconds
o   Reset water heaters to 120 degrees
Classification of Burns:
·       Depth of burns                                   : based on intensity and duration of thermal exposure
·       Superficial burns (1st degree)           : erythematous, painful
o   Only involve outer layer of epidermis (fluid loss not an issue)
o   Heal without scarring in 4-5 days
·       Partial thickness burns (2nd degree)
o   Superficial partial thickness: red and painful with blister formation
Partial destruction of dermis
Weeping/moist appearance
Healing in 7-10 days with minimal scarring
o   Deep partial thickness: greater than 50% of dermis lost
White, pale, less painful (nerve fibers destroyed)
2-3 weeks to heal, severe scarring can occur, contractures
May requires skin grafting
·       Full thickness burns (3rd degree): white, waxy, leathery
o   No bleeding, painless
o   High risk for infection and fluid loss
·       Fourth degree burn    : destruction of underlying structures – tendons, nerves, muscle, bone, deep fascia

Estimation of Burn Area (do not include superficial burns)            :
·       Adolescents/adults: rule of 9’s
o Head/Arm: 9% each
o Leg, anterior trunk, posterior trunk: 18%
o Neck and groin: 1% each
·       Children: surface of child’s palm = 0.5% TBSA
o Modified Lund and Brower chart (see image)


Friday, 2 November 2012

BREAST CANCER AT AGLANCE



INTRODUCTION
1.1. Background
Breast cancer is a malignant tumor derived from cells located in the breast. -Lobular breast consists of lobules, ducts, fatty and connective tissue, blood and lymph vessels. In general, cancer originating from the cells contained in the ducts, some of which came from the lobular and other tissues.
Breast cancer is a malignancy that affects nearly one-third of all malignancy found in women. Breast cancer is also the second leading cause of death after cervical cancer in women as well as occupying the highest incidence of all malignancies. Each year, more than one million new cases of breast cancer are diagnosed worldwide, and nearly 400,000 people will die from the disease. By 2003, breast cancer is the cancer with the highest incidence of 2 in Indonesia and there is a trend from year to year, the incidence is increasing, and as well as in western countries. The incidence of breast cancer in the United States 92/100.000 women per year with a high mortality 27/100.000 or 18% of the deaths were found in women. In Indonesia by "Pathological Based Registration" relative incidence of breast cancer has 11.5%. Indonesia has the incidence is estimated at a minimum of 20,000 new cases per year; with the fact that over 50% of cases are still in the advanced stages.
There are so many risk factors that can lead to the development of breast cancer. Statistically the risk of breast cancer in women increased in nullipara, early menarche, late menopause and in women who are pregnant her first child at the age of 30 years. A total of less than 1% of breast cancers occur in less than 25 years of age, after the age of 39 years the incidence increased rapidly. The highest incidence is found in the age of 45-50 years. While breast cancer in men in the epidemiology of less than 1% of all breast cancers.