The high rates of smoking will make lung cancer as one of the problems of health in Indonesia, such as the problems of other malignancies. Increased morbidity of malignant disease, such as cancer can be seen from the Household Health Survey (Survey) shows the death rate due to cancer is still around 1.01% to 4.5% in 19901. data made by WHO showed that lung cancer is a type of disease malignancy was the cause of death in the group of death from malignancy, not only in men but also in women. The poor prognosis of this disease may be closely related to the scarcity of patients come to the doctor when the disease is still in the early stages of the disease. The results of the study on postoperative lung cancer patients showed that, the average 5-year survival rate stage I very much different from those after stage II surgery, especially when compared with untreated advanced staging is 9 months. Lung cancer is one type of lung disease require handling and swift and focused action. Diagnosis of this disease requires skills and tools that are not simple and requires a multidisciplinary approach medicine. This disease requires close cooperation between experts and integrated pulmonary diagnostic radiologist, pathologist, radiologist therapy and thoracic surgeons, medical rehabilitation specialists and other experts. Disease treatment or containment procedures is highly dependent on the dexterity of lung experts to get a definite diagnosis. The discovery of lung cancer at an early stage will help the patient, and the discovery of the diagnosis in a faster time allowing patients gain a better quality of life in the course of the disease although it can not cure it. The choice of therapy should be immediately carried out, given the poor response to various types of lung cancer treatment. Even in some cases of lung cancer patients require a handler as soon as possible, although a definite diagnosis can not be enforced.
Lung cancer in its broadest sense is any disease in lung malignancies, including lung malignancy originating from outside itself and the malignancy of the lung (metastatic tumors in the lungs). In this management guidelines are intended to lung cancer is of primary lung cancer, the malignant tumor derived from bronchial epithelium or bronchial carcinoma (bronchogenic carcinoma). According to the present concept of cancer is a disease of genes. A normal cell can become cancerous cells by a variety of causes occurs when an imbalance between oncogene function with tumor suppresor genes in the process of growth and blossoms a sel.Perubahan or gene mutations that cause hiperekspresi oncogenes and / or lack / loss of gene function causes cell tumor suppresor grow and develop unchecked. This change goes in phases, known as the Multistep carcinogenesis . Changes in the chromosomes, such as chromosome loss or LOH heterogeniti also suspected as a mechanism of cell growth abnormalities in cancer cells. From various studies have to be known a few oncogenes that play a role in the carcinogenesis of lung cancer, among other genes myc, k-ras gene whereas tumor suppresor gene clusters antaralain, the p53 gene, rb gene. While changes in the chromosomal location of 1p, 3p and 9p frequently found in lung cancer cells.
Lung cancer is the growth of cancer cells that are not controlled in the lung tissue. The pathogenesis of lung cancer has not been completely understood. Looks like bronchial mucosal cells undergo metaplastic changes in response to chronic exposure to inhaled particles and injured lungs. In response to cellular injury, inflammatory reactions and processes will evolve. Basal cell proliferation and mucosal will have differentiated into mucus-secreting goblet cells. It seems that the activity is due to metaplastic columnar epithelium lining the turn of the squamous epithelium, which is accompanied by cellular atypia and increased mitotic activity which develops into mucosal dysplasia. Span of time this process has not been established, only estimated approximately between 10 to 20 years.
The origins of the causes of lung cancer cells still can not be explained. During these two theories evolve, Theory pleuripotential cell by Auerbach, which explains the deviations that occur in the process of stem cell differentiation into cells by Yesner lain.Teori small cells, which explains the small cell neoplasms transformed and evolved into cell kanker.Namun known that genetic mutations occur in p73, p53 and PRB, in addition to the role of the oncogene c-MYB, c-MYCA, mycc c-, c-raf, L-myc, N-myc, K-flavor, c-Fura, N-ras , H-ra, c-erbB1, c-fms, c-fes, c-rlf, c-erbB1, c-ErbB2, c-sis, BCL1.
According to WHO, lung cancer is the leading cause of death in the group of cancer in both men and women
Types of lung cancer:
1. Squamous cell carcinoma
2. Lung Adenocarcinoma
3. Adenocarcinoma bronkioalveolar
4. Carcinoma large cell
Classification of lung cancer defined by WHO standards,
I. Epithelial Tumors
1. Squamous cell a. spindle cell variant
2. Tiny cell a. wheat cells
b. intermediate cells
c. combination of wheat cells
3. Adeno a. acinar
d. Solid carcinoma with mucin formation
4. Larger cell a. giant-cell
6. Carcinoid tumors
7. Bronchial glands
II. Soft tissue tumors
III. Mesothelial tumors
IV. Other Tumors
V. secondary tumors
VI. Tumors that have not been classified
VII. Tumor-like lesions
More than 90% of lung cancers originated from the bronchi, to bronchogenic cancer is called carcinoma, which consists of:
1. squamous cell carcinoma
2. carcinoma small cell
3. carcinoma large cell
4. Lung Adenocarcinoma
Alveolar cell carcinoma originating from the alveoli in the lungs. This cancer can be a single growth, but often strike more than one area of the lung.
Lung tumors are less common are:
1. adenomas (either malignant or benign)
2. Hamartoma kondromatous (benign)
3. sarcoma (malignant)
Lymphoma is a cancer of the lymph system, which can be derived from the lung or is spread from other organs. Many cancers that originated elsewhere spread to the lungs. This cancer usually comes from the breast, colon, prostate, kidney, thyroid, stomach, cervix, rectum, testicles, bones and skin.
Squamous cell carcinoma
Called squamous cell carcinoma, or SCC in English, this type of cancer is common in the main bronchial tubes. Generally there is a development of keratin and keratin pearls.
Lung adenocarcinoma were recorded around 30% - 45% and will likely continue to increase. Cases of lung adenocarcinoma usually occurs in the lungs and organs are more common in women than in men, with a tendency to early metastasis in the area around the lymph nodes and brain. Patients with lung adenocarcinoma typically have a chronic history of interstitial lung disease, such as scleroderma, rheumatoid disease, sarcoidosis, interstitial pneumonitis, tuberculosis, recurrent lung infections or lung disease accompanied by necrosis. This causes scar carcinoma is often called adenocarcinomas.
A subtype of lung adenocarcinoma with an incidence rate of approximately 2% - 4% of the total incidence of lung cancer, often associated with several lung diseases that result in pulmonary fibrosis, such as pneumonia, idiopathic pulmonary fibrosis, granulomata, asbestosis, alveolitis with fibrosis, scleroderma, and disease Hodgkin. The place of this cancer is still being debated, but the possibility has been minimized between Clara cell population or type II pneumocytes along the alveolar septa propagating.
Large cell carcinoma
This cancer has an incidence rate of approximately 9%. Tumor cells characterized by large cells with large nuclei. Have not found the glandular or squamous differentiation.
There is a classification of lung cancer,'s seen from both dijaringan pulmonary diffusion rate itself and to other organs. But basically lung cancer is divided into two criteria based on the level of distribution:
1. primary lung cancer
Has two main types, namely Small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). SCLC is the type that sell small (many) which has a very rapid growth to swell. Usually called "oat cell carcinomas" (wheat cell carcinoma). This type is closely associated with smokers, Handling respond well enough through the action of chemotherapy and radiation therapy.
While the growth of NSCLC is a single sell, but often affects more than one area of the lung. For example adenoma, Hamartoma kondromatous and Sarcoma.
2. secondary lung cancer
Lung cancer is a disease that arises as a result of the spread of cancer from the other organs, most commonly breast cancer and colon cancer (stomach). Cancer spreads through the blood, lymphatic system or because of the proximity of the organ.
Lung cancer is responsible for most deaths due to cancer in men and women throughout the world. The American Cancer Society memperkirakna that 213.380 new cases of lung cancer will be diagnosed in the United States and 160.390 deaths due to lung cancer will occur in 2007. Lung cancer is largely a disease of the elderly; nearly 70% of people diagnosed with the condition are over 65 years old, which is less than 3% of cases occur in people under the age of 45 years.
Lung cancer was not common prior to the 1930s but increased dramatically over the following decades when the smoke rising. In many countries that are developing, the incidence of lung cancer is beginning to decline following the public education about the dangers of smoking and smoking cessation programs are effective. Nevertheless, lung cancer remains among the types most common cancer in both men and women throughout the world.
Lung cancer has also been passed in breast cancer resulted in the most deaths related to cancer in women in the United States.
Incidence of lung cancer is strongly associated with cigarette smoking, with about 90% of cancer-lung cancer arising as a result of tobacco use. The risk of lung cancer increases with the number of cigarettes smoked over time; doctors refer to this risk in terms of annual pack history of smoking (number of packs of cigarettes smoked per day multiplied by the number of years of exploitation). For example, a person who has smoked two packs of cigarettes per day for 10 years has a 20 pack year history. When the risk of lung cancer increases even with a 10 pack year smoking history, those with a history of 30 pack-year history or more considered to have the greatest risk of developing lung cancer. Among who smoke two or more packs of cigarettes per day, one in seven will die of lung cancer.
Pipe and cigar smoking can also cause lung cancer, although the risk is not as high as with cigarette smoking. Where a person who smokes one pack of cigarettes per day has a risk of developing lung cancer is 25 times higher than the non-smokers, smokers of pipes and cigars have a risk of lung cancer is approximately 5 times than someone who does not smoke.
Tobacco smoke contains over 4,000 chemical compounds, many of which have been shown to cause cancer, or carcinogenic. Two major in-carcinogenic carcinogenic tobacco smoke are chemicals known as nitrosamines and polycyclic aromatic hydrocarbons . The risk of developing lung cancer decreases each year due to smoking cessation as normal cells grow and replace damaged cells in the lung. In former smokers, the risk of developing lung cancer begins to approach that of a nonsmoker about 15 years after cessation of smoking.
Asbestos fibers (asbestos fibers) are silicate fibers (silicate fibers) that can persist for a lifetime in lung tissue due to exposure to asbestos. The workplace is a common source of exposure to asbestos fibers is common, because asbestos is widely used in the past for both of them, namely as heat insulation materials and acoustic. Today, asbestos use is limited or banned in many countries, including the United States. Both lung cancer and mesothelioma (a type of cancer of the pleura or lining of the abdominal cavity called the peritoneum ) are associated with exposure to asbestos. Mehisap smoking dramatically increases the chances of developing a lung cancer associated with asbestos-exposed workers. Asbestos workers who do not smoke have a risk of developing lung cancer five times than non-smokers, and asbestos workers who smoke have a risk of 50 to 90 times greater than nonsmokers.
Radon gas is a noble gas and natural chemical which is a breakdown product of natural uranium. He broke / crushed form products that emit a type of ionizing radiation. Radon gas is a known cause of lung cancer, with an estimated 12% of lung cancer deaths attributable to radon gas, or 15,000 to 22,000 deaths associated with lung cancer each year in the U.S., making radon the second leading cause of cancer lung in America. As with exposure to asbestos, smoking is simultaneously a very large increase in lung cancer risk with exposure to radon. Radon gas can move through the soil and into the house through gaps between the foundations, pipes, ducts, or other open places. The U.S. Environmental Protection Agency estimates that one out of every 15 homes in America contain levels of radon gas are dangerous. Radon gas is invisible and odorless, but it can be detected with a checkered simple test.
While the majority of lung cancers are associated with tobacco smoke, the fact that not all smokers eventually develop lung cancer suggests that other factors, such as individual genetic sensitivity, may play a role in causing lung cancer. Many studies have shown that lung cancer is likely to occur in both brothers who smoke and non-smokers who have had lung cancer than the general population. Recent research has localized a region on the long arm of human chromosome number 6 that is likely to contain a gene that confers an increased sensitivity of developing lung cancer in smokers.
The presence of certain lung diseases, especially chronic obstructive pulmonary disease (COPD), is associated with a slightly increased risk (four to six times the risk of a nonsmoker) for developing lung cancer even after the effects of cigarette smoking have been dispensed simultaneously.
Previous history of Lung Cancer
The survivors of lung cancer have a greater risk than the general population of developing a second lung cancer. The survivors of non-small cell lung cancers (NSCLCs, see below) have an additional risk of 1% -2% per year developing a second lung cancer. In those survivors of small cell lung cancers (SCLCs), the risk of developing second cancers approaches 6% per year.
Air pollution from vehicles, industry, and places of power generation (electricity) can increase the likelihood of developing lung cancer in exposed individuals. Up to 1% of lung cancer deaths are caused by breathing polluted air, and experts believe that prolonged exposure (long) at a very high polluted air can carry a risk similar to that of passive smoking to develop lung cancer.
The symptoms of lung cancer varies depending on where and how wide spread of the tumor. Warning signs of lung cancer are not always present or easy to identify. A person with lung cancer may have all kinds of the following symptoms:
· No symptoms : In up to 25% of people who get lung cancer, cancer is first discovered on a chest x-ray and CT scans on a regular basis as a small remote mass sometimes called a coin lesion (coin lesion ). These patients with single masses often report no small symptoms of lung cancer at the time it was found.
· What are the symptoms associated with cancer : cancer Pertumubuhan and assault (invasion) of lung tissues and the environment-the environment may interfere with breathing, leading to symptoms such as cough, shortness of breath, wheezing (wheezing), chest pain, and coughing up blood ( hemoptysis ). If the cancer has invaded nerves, for example, it may cause shoulder pain that moves down the outside of the arm (called Pancoast's syndrome ) or paralysis suaru bands leads to a hoarse voice (hoarse). Attack the esophagus may lead to difficulty swallowing ( dysphagia ). If a large airway is obstructed, mengempisnya portion of the lung may occur and cause infections (abscesses, pneumonia) in the obstructed area.
· Symptoms related to metastasis : Lung cancer that has spread to the bones may produce excruciating pain at the sites of bone involved. Cancer that has spread to the brain may cause a number of neurologic symptoms that may include blurred vision, headaches, attacks (seizures), or symptoms of stroke such as weakness or numbness in parts of the body.
· Paraneoplastic Symptoms : Lung cancers are often accompanied by so-called paraneoplastic syndromes that result from the production of the elements that resemble hormones by the tumor cells. Paraneoplastic syndromes occur most commonly with SCLC but may be seen with any tumor type. A common paraneoplastic syndrome associated with SCLC is the production of a hormone called adrenocorticotrophic hormone (ACTH) by the cancer cells, leading to excessive secretion of cortisol by the adrenal glands ( Cushing's syndrome ). Paraneoplastic syndromes (paraneoplastic syndrome) is most often seen with NSCLC is the production of a substance similar to parathyroid hormone, resulting in calcium levels are increased in the blood stream.
· Nonspecific Symptoms : nonspecific symptoms seen with many cancers, including lung cancer include weight loss, weakness, and fatigue. Psychological symptoms such as depression and mood changes are also common.
Lung cancer clinical picture is not much different from other lung diseases, comprising darikeluhan subjective and objective symptoms. Of history will be obtained and perjalananpenyakit main complaint, as well as other factors that are often very helpful establishment of the diagnosis. Utamadapat complaint form:
• Cough-cough with / without sputum (phlegm white, can also purulent)
• Coughing up blood
• Shortness of breath
• Chest Pain
• Difficulty / pain swallowing
• A lump in the base of the neck
• swollen face and neck, sometimes accompanied by swollen arm pain
Not infrequently the first visible symptoms or complaints are due to metastases outside the lung, such as disorder arising from intense compression in the brain, liver enlargement or broken tulangkaki.
Symptoms and complaints that are not typical such as:
• Weight loss is reduced
• Appetite lost
• intermittent fever
• paraneoplastic syndromes, such as "Hypertrophic pulmonary osteoartheopathy", venous thrombosis and peripheral neuropatia.
Chronology of Early Detection of Lung Cancer
B. Physical Examination
Physical examination should be done thoroughly and carefully. The results sangatbergantung on abnormalities on examination done. Lung tumor size is small and can give you an idea diperifer normal on examination. Tumors with large size, especially when accompanied by atelectasis due to bronchial compression, pleural effusion or venakava emphasis will provide a more informative. This examination can also provide datauntuk determination of the stage of disease, such as lymphadenopathy or tumors outside the lung. Another keorgan metastases can also be detected by palpation of the liver, funduscopic examination to mendeteksipeninggian intracranial pressure and the occurrence of fractures due to bone metastases.
The results of the radiological examination is one that is absolutely necessary investigations untukmenentukan primary and metastatic tumor sites, as well as disease staging based sistemTNM. Pulmonary radiological examination ie CXR PA / lateral, if possible thoracic CT scan, bone scan, Bone survey, abdominal ultrasound and CT Brain-disorders are needed to determine the location, size tumordan metastasis.
a. Chest X-ray: In radiographic examinations PA / lateral will be seen when the tumor future denganukuran tumors more than 1 cm. Signs that support malignancy was irregular edges, disertaiidentasi pleura, tumor satellite tumors, etc.. In the photos can also be found to have tumor invasion dindingdada, pleural effusion, effusion and metastasis perikar intrapulmoner. While the involvement of the KGB untukmenentukan N rather difficult to determine the radiographic saja.Kewaspadaan physician to the possibility of lung cancer in a patient's disease parudengan picture is not typical for malignancy is important to be reminded. A yangtergolong patients in high risk groups (GRT) with a diagnosis of lung diseases, should be accompanied by careful difollowup. Giving OAT showed no improvement or even deteriorate after 1bulan should rule out the possibility of lung cancer, but another problem pneumoniayang treatment is not successful after the administration of antibiotics for 1 week should also cause pneumonia dugaankemungkinan behind the tumor. If the chest X-ray showed a broad overview of pleural effusion should be followed by emptying isipleura with repeated puncture or insertion of WSD and repeat chest X-ray that can be shown when no tumorprimer. Malignancy should be contemplated when the fluid is productive, and / or cairanserohemoragik.
b.CT thoracic scan: This imaging technique can determine abnormalities in the lung better daripadafoto thorax. CT-scans can detect tumors with sizes smaller than 1 cm are more appropriate. Likewise, signs of malignant process also reflected better, even if terdapatpenekanan the bronchi, intra-bronchial tumor, atelectasis, pleural effusion and telahterjadi not massive invasion into the mediastinum and chest wall even without symptoms. Furthermore the CT-scan, the KGB's involvement was instrumental to determine the stage is also better because pembesaranKGB (N1 s / d N3) can be detected. Similarly, accuracy is the possibility to detect metastasisintrapulmoner.
Other radiological c.Pemeriksaan: Lack of chest radiograph and thoracic CT-scan is not mampumendeteksi the occurrence of distant metastases. That requires other radiological examinations, such as Brain-CT for detecting bone metastases in head / brain tissue, bone scan and / ataubone surveys can detect bone metastases throughout the body's tissues. Abdominal ultrasound can view the presence or absence of metastases in the liver, adrenal glands and other organs in the abdominal cavity.
Bronchoscopy is a diagnostic examination with the goal at once be counted on to dapatmengambil tissue or material in order to ensure the presence or absence of malignant cells. Intrabronkus adatidaknya examination period or changes in the airway mucosa, as shown abnormalities mukosatumor example, craggy, hyperemia, or infiltrative stinosis, bleed easily. Tampakan yangabnormal should be followed by tumor biopsy / bronchial wall, flushing, bronchial brushings ataukerokan.
b. Needle aspiration biopsy
If intrabronkial tumor biopsy can not be done, for example, because it is very easy to bleed, or if the slippery mucosal berbenjol, then needle aspiration biopsy should be performed, because danbiopsi bronchial washings alone often give negative results.
c. Transbronchial needle aspiration (TBNA)
TBNA in karina, or trachea 1/1 down (2 rings above the carina) at the 1 o'clock position when the tumor adadikanan, will provide dual information, which obtained the material for cytology and informasimetastasis subkarina or paratracheal nodes.
d.Transbronchial Lung Biopsy (TBLB)
If the lesion is small and somewhat in peripheral locations, and no means of fluoroscopic lung biopsy lewatbronkus (TBLB) should be performed.
e.Biopsi transthoracic (Transthoraxic Biopsy, TTB)
If the lesion is located in the peripheral and more than 2 cm in size, with the help of TTB flouroscopic angiography . however if lesions smaller than 2 cm and located in the central TTB can be performed with CT scan guidance.
f. Another biopsy
Fine-needle biopsy can be performed if there is a palpable lymphadenopathy or superficial dapatterlihat period. BECs biopsy should be done when palpable lymphadenopathy supraclavicular, axillary leheratau, especially when cytological diagnosis / histology of the primary tumor in the lung is unknown. BiopsiDaniels recommended when no obvious lymphadenopathy tidakmenghasilkan suparaklavikula and other means of information about this type of cancer cell. Puncture and pleural biopsy should be performed if adaefusi pleura.
With this action the tumor mass in this part of the peripheral lung, visceral pleura, parietal pleura can be seen and biopsied danmediastinum.
h. Sputum Cytology
Sputum cytology is a diagnostic measures are most easily and cheaply. Pemeriksaanini shortage occurs when there is a tumor in the peripheral, dry cough and collection techniques and pengambilansputum are not eligible. With the help of 3% saline inhalation for sputum merangsangpengeluaran can ditingkatkan.Semua material taken with the above checks should be sent to the Anatomic laboratoriumPatologi for cytology / histology. Materials should be sent segeratanpa fixation fluid, or smears made, and then fixed with absolute alcohol, or at least alkohol90%. All materials must be fixed networks dalamformalin 4%.
Other invasive testing
In the case of complicated cases sometimes invasive measures such as Thoracoscopy and action bedahmediastinoskopi, thoracoscopic, exploratory thoracotomy and open lung biopsy is needed in order diagnosisdapat enforced. This action is the last resort when all manner of telahdilakukan examination, diagnosis histological / pathological diagnosis can not ditegakkan.Semua action for lung cancer is directed to be determined:
1. Histological type.
2. Degrees (staging).
3. Views (levels appear, "performance status").
So that kind of treatment can be chosen according to the condition of the patient.
International Penderajatan Based Lung Cancer TNM System
occult carcinoma: Tx N0 M0
0: Tis N0 M0
IA: T1 N0 M0
IB: T2 N0 M0
IIA: T1 N1 M0
IIB: T2 N1 M0
IIIA: T3 N0 M0
T3 N2 M0
IIIB: any T N3 M0
T4 any N M0
IV: sembarangT any arbitrary N T
Category TNM for Lung Cancer
T : Primary Tumor
To : No evidence of primary tumor.
Difficult to assess the primary tumor, or primary tumor cells as evidenced by the discovery of a malignant tumor in bronchopulmonary secretions but does not appear to be radilogis or bronchoscopic.
Tx : primary tumor is difficult to assess, or primary tumor cells as evidenced by the discovery of a malignant tumor in bronchopulmonary secretions but does not appear to be radilogis or bronchoscopic.
Tis : Carcinoma in situ
T1 : The tumor with a diameter not exceeding 3 cm in the largest, surrounded by a network of lung or visceral pleura invasion and bronchoscopic no more proximal than lobar bronchus (not yet up to the lobar bronchus (not yet up to the main bronchus). Tumor any size with superficial invasive component limited to the walls of the bronchi that extends into the proximal main bronchus
T2 : Each tumor the size or expansion as follows:
- The diameter of more than 3 cm in greatest
- Regarding the main bronchus as far as 2 cm or more distal to the carina of the pleura visceral
- Associated with atelectasis or obstructive pneumonitis that extends to the area
hilum, but not the entire lung.
T3 : Tumor any size with direct extension to the chest wall (including superior sulcus tumors), diaphragm, mediastinal pleura or bronchial tumor in the main a distance of less than 2 cm distal to the carina, or tumor associated with atelectasis or obstructive pneumonitis of the entire lung.
T4 : Tumor any size of the mediastinum or heart, great vessels, trachea, esophagus, vertebral body, carina, tumors were accompanied by pleural effusion malignant or ipsilateral satellite tumor nodules in the same lobe as the primary tumor.
N : regional lymph nodes (KGB)
Nx : Lymph nodes can not be assessed
No : Not proven lymph node involvement
N1 : Metastasis in lymph nodes peribronkial and / or ipsilateral hilar, including direct tumor extension
N2 : Metastasis in ipsilateral lymph nodes mediatinum and / or KGB subkarina
N3 : Metastasis in contralateral mediastinal or hilar or KGB scalenus / supraklavila ipsilateral / contralateral
M Metastasis (spread child) away.
MX : Metastasis can not be assessed
Mo : No distant metastasis was found
M1 : distant metastasis was found. "Metastastic tumor nodule" (s) outside the ipsilateral lobe of the primary tumor is considered as M1
a. Tumor markers
Tumor markers that have, such as CEA, Cyfra21-1, NSE and other unusable untukmendiagnosis but still used in the evaluation of treatment outcomes.
b. Examination of molecular biology
Examination of molecular biology has been growing, the simplest way to menilaiekspresi multiple genes or gene products associated with lung cancer, such as p53 protein, bcl2, and others. The main benefit of the examination is to determine the molecular biology prognosispenyakit.
To determine the histological type, in more detail according to the WHO histological classification used tahun1999 (Appendix 1), but for the clinical needs enough if only knowable:
1. Squamous carcinoma (epidermoid carcinoma)
2. Small cell carcinoma (small cell carcinoma)
3. Adenocarcinoma (adenocarcinoma)
4. Large cell carcinoma (large cell carcinoma)
Various limitations often lead to specialist physicians experienced Anatomical Pathology kesulitanmenetapkan types of cytological / histological right. Therefore, for the sake of the choice of therapy, at least harusditetapkan, whether including small cell carcinoma lung cancer (small cell or lungcancer KPKSK, SCLC) lung cancer or non-small cell carcinoma (KPKBSK, nonsmall cell lung cancer, NSCLC).
Lung cancer treatment is combined modality therapy (multi-modaliti therapy). In fact on saatpemilihan therapy, often not only expected to histologic type, degree and display patient sajatetapi also non-state facilities for the dimilikirumah medisseperti pain sufferers and economic jugamerupakan the crucial factor.
Indications of surgery in lung cancer is to KPKBSK stage I and II. Surgery jugamerupakan part of "a combined modality therapy", such as neoadjuvant chemotherapy for stage IIIA. Another indication is when there is gravity that require surgical intervention, such as the vena cava syndrome kankerparu superiror berat.Prinsip surgically resected tumor was complete as much as possible following KGBintrapulmoner network, lobectomy or pneumonectomy with. Segmentektomi or wedge resection hanyadikerjakan if pulmonary function is not enough to lobectomy. Incision edges examined by frozen section toensure that limit tumor-free bronchial incision. Mediastinal nodes were taken with diseksisistematis, and examined other important pathologies important anatomis.Hal remembered before performing surgery is knowing the type of toleransipenderita surgery to be performed. Tolerance of the patient to be dibedahdapat measured by pulmonary function test values and if not can be judged from the results allow the analysis of blood gases (ABG):
Terms for lung resection
. mild risk for pneumonectomy, the contralateral lung bilaKVP well, VEP1> 60%
. risk being pneumonectomy, the contralateral lung bilaKVP> 35%, VEP1> 60%
Radiotherapy in lung cancer can be curative or palliative therapy. In curative therapy, neoadjuvant chemotherapy radioterapimenjadi part of stage IIIA to KPKBSK. In certain circumstances, radiotherapy alone is not infrequently an alternative curative therapy.
Radiation is often an emergency measure that must be done to relieve the patient complaints, such superiror vena cava syndrome, bone pain due to tumor invasion into the chest wall and metastasistumor in bone or brain.
Determination of radiation policy on several factors determined KPKBSK
1. Staging of disease
2. Status display
3. Pulmonary Function
When the radiation is done after surgery, it must be known:
- Type of surgery including node dissection is done
- Assessment by an incision limits Anatomical Pathology (PA)
The radiation dose given in general is 5000 - 6000 cGy, by way of 200 cGy / x, 5hari week.
Standard terms before the patient is irradiated is:
1. Hb> 10 g%
2. Platelets> 100.000/mm3
Palliative radiation given to unfavorable group, namely:
1. The PS <70.
2. Decline BB> 5% in 2 months.
3. Poor lung function.
Chemotherapy may be given in all cases of lung cancer. The main requirement to be determined jenishistologis tumor and appearance (performance status) and must be 60 or 2menurut Karnosfky scale according to the WHO scale. Chemotherapy uses anticancer drugs dalamkombinasi some chemotherapy regimens. In certain circumstances, the use of one type of anti-cancer drugs dapatdilakukan.
Recurrence (relapse) of lung cancer is highest in 2 years First, the making of evaluation in patients who have been treated optimally performed every 3 months. Pemeriksaanklinis and radiological evaluation included chest radiograph is PA / lateral and Ct-scan of thorax, while the other tests performed on the indication.
Preventing Lung Cancer
Smoking cessation is the steps / actions most important to prevent lung cancer. Many products, such as nicotine gum, nicotine sprays, nicotine inhalers or inhaler, may be beneficial for people who are trying to quit smoking. Shrink exposure to passive smoking is also an effective preventive measures. Using a home radon test box can identify and allow correction of radon levels in homes increase, which also can cause lung cancers. Methods for early detection methods that allow cancers, such as low-dose helical CT scans, may also be useful in identifying small cancers that can be cured by surgical resection and prevention of widespread cancer and incurable.
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2. Soelarto, Reksoprodjo. Set of Surgery Lecture, Jakarta: Binarupa Aksara.1995.
3. Sabiston, David C. Textbook of Surgery Part 2 . Jakarta: EGC 1994.